One case of rare autoimmune hemolytic syndrome, paroxysmal cold hemoglobinuria
(PCH) is reported.
PCH is one of the rarest of the autoimmune hemolytic syndrome, characterized by
acute intermittent hemolysis, frequently with hemoglobinuria, abdominal pain and periodic
attacks of fever, following local or general exposure to cold, and then a positive
Donath-Landsteiner test, positive Ehrlich reaction test, occasionally positive Rosenbach
test, and/or often associated with syphilis and recent viral infection.
The present case was admitted with chief complaints of headache, dizziness and
occasionally abdominal pain.
According to several : laboratory findings, the case which we have presented here was
thought to be compatible with paroxysmal cold hemoglobinuria associated with syphilis.
The patient appeared to show poor clinical improvement in response to prednisolone in
dose of 30mg per day, blood transfusion and other conservative management.
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